Development of tools for non-invasive human spinal cord research

开发非侵入性人类脊髓研究工具

• 批准号: 184139-2008
• 负责人: Stroman, Patrick
• 金额: $ 1.61万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=497801
• 关键词: Development; tools; non; invasive; human

Our knowledge of human spinal cord anatomy and function comes from invasive studies of anaesthetized animals, and from observations of the effects of injuries in humans, and from post-mortem studies. While these have yielded a wealth of information, there are still features that are poorly understood. The development of magnetic resonance imaging (MRI) has made it possible to observe human internal anatomy non-invasively, and functional MRI (fMRI) has enabled mapping of neuronal activity in response to a stimulus. Studies carried out in my lab with these methods have revealed previously unknown features of anatomy and function. For example, a link has been observed between attention to a sensation and neuronal activity in the spinal cord. We have also discovered that the motion of the spinal cord that occurs with each heart-beat decreases in amplitude lower in the cord, and the lumbar region is essentially motionless. This latter finding is the basis for the first part of this proposal.

我们对人类脊髓解剖学和功能的了解来自麻醉动物的侵入性研究，以及对人类损伤影响的观察和死后研究。 虽然这些研究提供了丰富的信息，但仍有一些特征尚不为人所知。 磁共振成像（MRI）的发展使得非侵入性地观察人体内部解剖结构成为可能，并且功能性MRI（fMRI）使得能够映射响应于刺激的神经元活动。 在我的实验室里用这些方法进行的研究揭示了以前未知的解剖和功能特征。 例如，在对感觉的注意力和脊髓中的神经元活动之间已经观察到了联系。 我们还发现，随着每次心跳发生的脊髓运动在脊髓下部的幅度减小，并且腰部区域基本上是静止的。 后一项调查结果是本建议第一部分的基础。