understanding the role of glutamatergic septal neurons for hippocampal function

了解谷氨酸能间隔神经元对海马功能的作用

• 批准号: 238770-2010
• 负责人: Williams, Sylvain
• 金额: $ 1.97万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=455027
• 关键词: understanding; role; glutamatergic; septal; neurons

For the last 50 years, the medial septum has been tought to be of critical importance for learning and memory because of its proposed role in generating hippocampal theta oscillations. The prevalent model in this field is that cholinergic and GABAergic neurons located in the medial septum project to the hippocampus and provide a pacemaker for hippocampal neurons. However, we have described in 2003 a third type of neuron in the medial septum that uses glutamate as a neurotransmitter and that project to the hippocampus. Despite the potential important role these "new" neurons may have in learning and memory, very little is know about these neurons. Our first objectives is to determine what the targets in hippocampus of these septal glutamate neurons. Second, using a transgenic mouse, we will determine the firoing ability of these neurons in contrast to other

在过去的50年里，内侧隔被认为对学习和记忆至关重要，因为它在产生海马体θ波振荡中起着重要作用。该领域流行的模型是位于内侧隔膜的胆碱能神经元和gaba能神经元向海马体投射，并为海马体神经元提供起搏器。然而，我们在2003年描述了第三种类型的神经元在内侧隔膜，使用谷氨酸作为神经递质，并投射到海马体。尽管这些“新”神经元可能在学习和记忆中发挥着潜在的重要作用，但人们对这些神经元知之甚少。我们的第一个目标是确定这些间隔谷氨酸神经元在海马体中的目标是什么。其次，使用转基因小鼠，我们将确定这些神经元与其他神经元相比的放电能力