Structure/function of CaMk II as a frequency decoder of calcium oscillations

CaMk II 作为钙振荡频率解码器的结构/功能

• 批准号: 250127-2007
• 负责人: DeKoninck, Paul
• 金额: $ 3.06万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=455579
• 关键词: Structure; function; CaMk; II; frequency

The calcium ion is a ubiquitous signaling element that is involved in diverse cellular processes including proliferation, differentiation, fertilization, secretion, contraction, neurotransmission, gene expression and apoptosis. In response to many cellular stimuli, such as hormones, antigens, neurotransmitters, and during cell contraction, free intracellular calcium rapidly and transiently increases in the form of spikes and waves, which give rise to localized calcium oscillations. The number, duration, amplitude and, particularly, the frequencies of these oscillations encode information about the nature of the external stimuli, which cells must locally decode into specific downstream cellular processes.

钙离子是一种普遍存在的信号元件，参与多种细胞过程，包括增殖、分化、受精、分泌、收缩、神经传递、基因表达和细胞凋亡。细胞受到激素、抗原、神经递质等多种刺激后，在细胞收缩过程中，细胞内游离钙以尖峰和波动的形式迅速而短暂地增加，从而引起局部的钙振荡。这些振荡的数量、持续时间、幅度，特别是频率，编码了有关外部刺激性质的信息，细胞必须在当地将这些信息解码为特定的下游细胞过程。