Role of the atypical MAP kinase ERK3 in T cell biology

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T cells, a type of white blood cells, patrol the organism to detect the presence of infectious agent. Antigenic fragment coming from infectious agent are presented to T cells in association with self-molecules of the major histocompatibility complex (MHC), by specialized cells of the immune system. The recognition of foreign substances (or antigens) by T cells via their T cell receptor (TCR), induced a variety of responses that will permit the elimination of the pathogen. Thus, T cells are crucial to fight life-threatening microbes. One goal of our research program is to identify the signals that are needed to generate an efficient response by T cells.