Role of the atypical MAP kinase ERK3 in T cell biology

非典型 MAP 激酶 ERK3 在 T 细胞生物学中的作用

• 批准号: 262146-2009
• 负责人: Labrecque, Nathalie
• 金额: $ 2.33万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=525514
• 关键词: Role; atypical; MAP; kinase; ERK3

T cells, a type of white blood cells, patrol the organism to detect the presence of infectious agent. Antigenic fragment coming from infectious agent are presented to T cells in association with self-molecules of the major histocompatibility complex (MHC), by specialized cells of the immune system. The recognition of foreign substances (or antigens) by T cells via their T cell receptor (TCR), induced a variety of responses that will permit the elimination of the pathogen. Thus, T cells are crucial to fight life-threatening microbes. One goal of our research program is to identify the signals that are needed to generate an efficient response by T cells.

T 细胞是白细胞的一种，在生物体中巡逻以检测传染源的存在。来自感染原的抗原片段由免疫系统的专门细胞与主要组织相容性复合体 (MHC) 的自身分子结合呈递给 T 细胞。 T 细胞通过 T 细胞受体 (TCR) 识别外来物质（或抗原），诱导多种反应，从而消除病原体。因此，T 细胞对于对抗危及生命的微生物至关重要。我们研究项目的目标之一是识别 T 细胞产生有效反应所需的信号。