Development of Multivalent Hyaluronan Derivative Therapeutics

多价透明质酸衍生物疗法的开发

• 批准号: ARC : LP0219363
• 负责人: Dr Jennifer Wilson
• 金额: $ 6.76万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-multivalent-hyaluronan-derivative-therapeutics/64688
• 关键词: Development; Multivalent; Hyaluronan; Derivative; Therapeutics

Development of Multivalent Hyaluronan Derivative Therapeutics. Over-expression of the hyaluronan receptor CD44 has been identified at pathological sites of diseases such as cancer, psoriasis, arthritis and asthma. The research described in this proposal aims to develop novel therapeutic compounds which target CD44 whilst eliciting a therapeutic index. The design of these new therapeutics is based on a template structure which incorporates known cytotoxic or anti-fungal agentsas well as hyaluronan, a naturally occurring carbohydrate, ubiquitous in nature.

多价海洛烷衍生物治疗药物的开发。透明质酸受体CD44的过表达已经在疾病如癌症、牛皮癣、关节炎和哮喘的病理部位被鉴定。该提案中描述的研究旨在开发靶向CD44的新型治疗化合物，同时引发治疗指数。这些新疗法的设计是基于一种模板结构，该结构包含已知的细胞毒性或抗真菌剂以及透明质酸，透明质酸是一种天然存在的碳水化合物，在自然界中无处不在。