MicroRNA regulation of smooth muscle development

MicroRNA 调节平滑肌发育

• 批准号: 312496-2009
• 负责人: Childs, Sarah
• 金额: $ 2.55万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=457451
• 关键词: MicroRNA; regulation; smooth; muscle; development

We are interested in discovering the genetic pathways that lead to organ development, particularly in the gut and blood vessels. Both of these organs consist of multiple tissue layers, one of which is smooth muscle. Smooth muscle provides the contractility of the gut for digestion and contraction of blood vessels to modulate blood pressure. In this proposal we will explore how a small nucleic acid, miR-143, controls the expression of other genes during development of smooth muscle. We will do this by determining which genes miR-143 regulates, and then understanding how these genes act together to co-ordinate the proper development of smooth muscle.

我们有兴趣发现导致器官发育的遗传途径，特别是在肠道和血管中。这两种器官都由多个组织层组成，其中之一是平滑肌。平滑肌为消化和血管收缩提供肠道收缩力以调节血压。在本提案中，我们将探索小核酸miR-143如何控制平滑肌发育过程中其他基因的表达。我们将通过确定miR-143调节哪些基因来实现这一点，然后了解这些基因如何共同作用以协调平滑肌的正常发育。