Mechanism/inibition of anthrax lethal factor and development of optical anion chemosensors

炭疽致死因子的作用机制/抑制及光学阴离子化学传感器的开发

• 批准号: 312629-2010
• 负责人: Siemann, Stefan
• 金额: $ 1.97万
• 依托单位: Laurentian University of Sudbury
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=457513
• 关键词: Mechanism; inibition; anthrax; lethal; factor

Zinc is an essential element, and an indispensable constituent of more than 300 enzymes involved in many critical biological processes. My research program seeks to understand how these enzymes work on the molecular level. Our primary focus of study is the anthrax lethal factor (LF), a zinc-dependent metalloenzyme, which constitutes one of the three components of the anthrax toxin. One of the other components of this toxin is termed protective antigen (PA). PA forms a pore in the membranes of host cells, thus allowing LF to enter the host cell, where it exerts its deleterious action.

锌是一种必需元素，是参与许多关键生物过程的300多种酶的不可缺少的组成部分。我的研究项目旨在了解这些酶如何在分子水平上起作用。我们的主要研究重点是炭疽致死因子（LF），一种锌依赖性金属酶，它构成炭疽毒素的三种成分之一。这种毒素的其他成分之一被称为保护性抗原（PA）。PA在宿主细胞的细胞膜上形成一个孔，从而允许LF进入宿主细胞，并在那里发挥其有害作用。