Presynaptic contributions in synaptic plasticity

突触前对突触可塑性的贡献

• 批准号: 341403-2008
• 负责人: Wong, TakPan
• 金额: $ 1.58万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=458362
• 关键词: Presynaptic; contributions; synaptic; plasticity

Communication between cells is the core issue of biological science. In the brain, communication takes place at a specialized structure named the synapse. In addition to functioning as an information gateway between brain cells, it is well known that the strength of synapses can undergo long-term changes in an experience-dependent manner. This plastic property of synapse, which is termed as synaptic plasticity, is the cellular model for learning and memory. Thus, understanding the biological mechanisms of synaptic plasticity will greatly advance our knowledge of how memory is formed in the brain.

细胞间的交流是生物科学的核心问题。在大脑中，交流发生在一个名为突触的特殊结构上。除了作为脑细胞之间的信息门户之外，众所周知，突触的强度可以通过经验依赖的方式经历长期的变化。突触的这种可塑性被称为突触可塑性，是学习和记忆的细胞模型。因此，了解突触可塑性的生物学机制将极大地促进我们对记忆是如何在大脑中形成的知识。