Stress and hippocampal volume in rodents, a longitudinal study

啮齿动物的压力和海马体积，一项纵向研究

• 批准号: RGPIN-2015-04844
• 负责人: Wong, TakPan
• 金额: $ 1.75万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590054
• 关键词: Stress; hippocampal; volume; rodents; longitudinal

The impact of stress on memory is at least partly due to its influences on the hippocampus, a brain region that is important for learning and memory. Although chronic stress could reduce hippocampal volume, the functional significance of hippocampal shrinkage remains unclear. The difficulty of understanding the functional significance of hippocampal shrinkage may be partly caused by the almost exclusive use of a cross-sectional approach to investigate hippocampal volume differences between stressed and non-stressed individuals. Cross-sectional studies however fail to reveal causality. Another problem is related to the failure to control for individual differences in stress susceptibility in most stress studies. Investigating psychopathologies in people that had experienced wide scale traumatic events revealed that not all people are similarly affected by these events, so that some individual were resilient to trauma.

压力对记忆的影响至少部分是由于它对海马体的影响，海马体是一个对学习和记忆很重要的大脑区域。尽管慢性压力可以减少海马体积，但海马收缩的功能意义仍不清楚。理解海马收缩的功能意义的困难可能部分是由于几乎完全使用横断面方法来研究压力和非压力个体之间的海马体积差异造成的。然而，横断面研究未能揭示因果关系。另一个问题与大多数压力研究未能控制压力敏感性的个体差异有关。对经历过大规模创伤事件的人的精神病理学进行的调查显示，并非所有人都受到这些事件的类似影响，因此有些人对创伤具有复原力。