Cellular mechanisms of material-associated thrombosis

虽然心血管装置大大延长了数百万人的预期寿命，但它们的使用并非没有并发症。尽管抗凝和抗血小板治疗，血栓（血栓）继续发生在心血管装置，如支架和心脏瓣膜。其后果可能是致命的，治疗这些血栓性并发症的费用也很高。虽然大多数关于血栓形成的研究都忽略了白细胞（白细胞）的作用，但我自己的研究表明，它们可能具有显著的影响。通过体外实验，血液接触机械心脏瓣膜和支架中使用的材料，本研究将更详细地研究白细胞在存在材料的情况下在血栓形成中所起的作用。将特别强调物质、白细胞和其他血液成分（如血小板）之间的相互作用。这是一种整体方法，可以识别经常被忽视的交互。因此，这将确定药物治疗和表面修饰的潜在靶点，有效降低心血管装置血栓形成的发生率。

While cardiovascular devices have significantly increased the life expectancy of millions of people, their use is not without complications. Despite anticoagulant and anti-platelet therapies, blood clots (thrombus) continue to occur with cardiovascular devices such as stents and heart valves. The consequences may be fatal and the cost to treat these thrombotic complications is significant. While most research on thrombus formation has ignored the role of white blood cells (leukocytes), my own research has shown that they may have a significant impact. Using in vitro experiments, whereby blood contacts materials used in mechanical heart valves and stents, this research will examine in more details the role that leukocytes play in thrombus formation in the presence of a material. Particular emphasis will be placed on the interactions between the material, leukocytes and other components of blood such as platelets. This is a holistic approach which will identify interactions that are often overlooked. As a result, this will identify potential target for drug therapies and surface modifications that effectively reduce the incidence of thrombus formation with cardiovascular devices.