Development of biocompatibility testing and strategy for implantable biosensors

植入式生物传感器生物相容性测试和策略的开发

• 批准号: 523518-2018
• 负责人: Gorbet, Maud
• 金额: $ 1.82万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=652178
• 关键词: Development; biocompatibility; testing; strategy; implantable

This project is the first collaboration between Gorbet's Material Interactions with Biological Systems lab and**NERv, a startup company, developing an implantable device to monitor post-surgical complications. This**6-month project aims to develop a set of in vitro models allowing NERv to investigate mechanisms involved in**biosensor and device biocompatibility as well as develop a strategy to ensure the long term biocompatibility**and performance of their implantable device.**There is currently limited research available on the biocompatibility of nanomembrane materials and how**combining various materials to hold and seal an implantable monitoring device will impact cell response. This**project aims to develop in vitro models to investigate the response of blood cells (platelets and leukocytes) and**macrophages to the NERv biosensing membrane as well as encapsulating and sealant materials alone or in**combination and determine the mechanisms involved in cell activation and the impact of combining various**materials.**The knowledge created will be key to NERv's product development and sensor performance testing. This R&D**project will contribute to the success of NERv, and will result in the creation of new jobs and training**opportunities in nanotechnology and biomedical engineering in Ontario.

这个项目是Gorbet的材料与生物系统相互作用实验室和创业公司**NERv之间的第一次合作，开发一种可植入的设备来监测术后并发症。这个为期6个月的项目旨在开发一套体外模型，使NERv能够研究生物传感器和设备生物相容性的机制，并制定策略来确保其植入式设备的长期生物相容性和性能。**目前，关于纳米膜材料的生物相容性以及如何结合各种材料来保持和密封可植入的监测设备将影响细胞反应的研究有限。本**项目旨在建立体外模型，研究血细胞（血小板和白细胞）和**巨噬细胞对NERv生物传感膜以及单独或联合使用的包封和密封材料的反应，确定细胞活化的机制以及各种**材料联合使用的影响。**所创造的知识将是NERv产品开发和传感器性能测试的关键。这个研发项目将有助于NERv的成功，并将在安大略省纳米技术和生物医学工程领域创造新的就业机会和培训机会。