Discovery Projects - Grant ID: DP0208662

发现项目 - 拨款 ID：DP0​​208662

• 批准号: ARC : DP0208662
• 负责人: Jason Harper
• 金额: $ 20.21万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 资助国家: 澳大利亚
• 起止时间: 0100-11-30 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/discovery-projects-grant-id-dp0208662/1789494
• 关键词: Discovery; Projects; Grant; ID; DP0208662

Characterisation and Development of Dynamic Supramolecular Combinatorial Libraries. The discovery of biologically active molecules, in particular drug discovery, requires the design and synthesis of host molecules that bind selectively to the biological target. Combinatorial chemistry has greatly assisted this discovery process as it allows the rapid screening of large collections of molecules. In this proposal, metal ion interactions will be used in the combinatorial library as this will greatly increases the diversity of the pool of compounds to be screened for activity. Understanding how to generate and analyze these libraries has potential applications in drug screening, the discovery of new substrates, enzymes and inhibitors.

动态超分子组合库的表征与发展。生物活性分子的发现，特别是药物发现，需要设计和合成选择性结合生物靶标的宿主分子。组合化学极大地帮助了这一发现过程，因为它允许快速筛选大量的分子。在该提议中，金属离子相互作用将用于组合文库中，因为这将大大增加待筛选活性的化合物库的多样性。了解如何产生和分析这些文库在药物筛选、发现新底物、酶和抑制剂方面具有潜在的应用。