Discovery Projects - Grant ID: DP0208662

点击翻译按钮获取中文摘要

Characterisation and Development of Dynamic Supramolecular Combinatorial Libraries. The discovery of biologically active molecules, in particular drug discovery, requires the design and synthesis of host molecules that bind selectively to the biological target. Combinatorial chemistry has greatly assisted this discovery process as it allows the rapid screening of large collections of molecules. In this proposal, metal ion interactions will be used in the combinatorial library as this will greatly increases the diversity of the pool of compounds to be screened for activity. Understanding how to generate and analyze these libraries has potential applications in drug screening, the discovery of new substrates, enzymes and inhibitors.