In vitro methods to optimize inhalable nanoparticles

优化可吸入纳米颗粒的体外方法

• 批准号: 372421-2008
• 负责人: Loebenberg, Raimar
• 金额: $ 2.59万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=461626
• 关键词: vitro; methods; optimize; inhalable; nanoparticles

Today there is only limited information available about the therapeutic efficacy, interaction, toxicity of nano-sized delivery systems with lung epithelia cells and alveolar macrophages. A mechanistic assessment of the different effects an active principle (e.g. drug), excipients (e.g. matrix material) or a nanoparticle and a combination of all of them as a drug delivery system needs to be performed.

目前，关于纳米级递送系统与肺上皮细胞和肺泡巨噬细胞的治疗功效、相互作用和毒性的信息非常有限。需要对活性成分（例如药物）、赋形剂（例如基质材料）或纳米颗粒以及它们的组合作为药物递送系统的不同作用进行机械评估。