N-acylated hexosamines as nutraceuticals : from shellfish to algae to mammalian bone and joint health

N-酰化己糖胺作为营养保健品：从贝类到藻类再到哺乳动物的骨骼和关节健康

• 批准号: 381564-2009
• 负责人: Anastassiades, Tassos
• 金额: $ 13.73万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Strategic Projects - Group
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=463384
• 关键词: acylated; hexosamines; nutraceuticals; shellfish; algae

Glucosamine (GlcN) is used extensively as an "over the counter" preparation for joint and bone disorders. However, it is not clear from clinical trials that it actually works. The main source GlcN is chitosan, which is derived from chitin, the most abundant polymer in the animal kingdom. So GlcN is a "nutraceutical". We have developed a series N-acylated glucosamines (GlcNAcyls), which are chemically modified nutriceuticals, for veterinary and human applications, primarily in arthritis and osteoporosis. Our preferred (lead) compound, N-butyryl glucosamine (GlcNBu) has shown positive effects in animal models for these applications, GlcN itself has not. Other applications, for which we have preliminary data, include enhancing animal growth and weight gain and possibly cognition and increased mobility in aged dogs. GlcNBu appears to have very little, if

氨基葡萄糖（GlcN）被广泛用作关节和骨骼疾病的“非处方”制剂。然而，临床试验并不清楚它是否真的有效。GlcN的主要来源是壳聚糖，其衍生自甲壳素，甲壳素是动物界中最丰富的聚合物。所以GlcN是一种“营养品”。我们已经开发了一系列N-酰化氨基葡萄糖（GlcNAcyls），这是化学修饰的营养品，用于兽医和人类应用，主要用于关节炎和骨质疏松症。我们优选的（先导）化合物N-丁酰葡糖胺（GlcNBu）在这些应用的动物模型中显示出积极的作用，GlcN本身没有。我们有初步数据的其他应用包括促进动物生长和体重增加，以及可能的认知和增加老年犬的流动性。GlcNBu似乎很少，如果