Unprecedented transpositions and their applications in the synthesis of bioactive compounds

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Synthesis of new bioactive compounds as new treatments for cancer, cardiovascular diseases and other nosocomial infections represents a continuing challenge for the pharmaceutical industry. Most of the compounds demonstrating useful biological properties against these diseases possess a heterocyclic or a polycyclic skeleton such as platencin, platensimycin, steroids, hamayne, rotunol and fawcettimine. Unfortunately, the natural abundance of these compounds is low and their extraction causes damage to our ecosystem. Consequently, it is extremely important to discover new synthetic methods to obtain these structures rapidly for potential biomedical application. In this context, the collaborative research project presented in this proposal in collaboration with the pharmaceutical company Boehringer Ingelheim is dedicated