Mammalian histidine kinase: its characterisation and role in hepatic cellular proliferation

哺乳动物组氨酸激酶的特性及其在肝细胞增殖中的作用。蛋白激酶调节细胞代谢的各个方面，但有一类蛋白激酶，组氨酸激酶，存在于哺乳动物细胞中，对它的了解非常少。该项目将是第一个详细描述这种酶的特性并研究其细胞功能的项目。待表征的酶是肝性的，并且它涉及再生肝脏中DNA复制的调节。我们将获得一个详细的图片，这组氨酸激酶在肝细胞生物学的作用，并深入了解这类酶的更一般的生物学作用。

Mammalian histidine kinase: its characterisation and role in hepatic cellular proliferation. Protein kinases regulate all aspects of cellular metabolism, but there is a class of protein kinase, histidine kinases, which exists in mammalian cells, about which remarkably little is understood. This project will be the first detailed characterisation of such an enzyme and investigation of its cellular function. The enzyme to be characterised is hepatic and it has been implicated in the regulation of DNA replication in regenerating liver. We shall obtain a detailed picture of the role of this histidine kinase in liver cell biology and an insight into the more general biological role of this class of enzyme.