Novel vaccines and serotyping scheme for Haemophilus parasuis

副猪嗜血杆菌的新型疫苗和血清分型方案。由副猪嗜血杆菌（Haemophilus parasuis）引起的格拉瑟氏病（Glasser's disease）是澳大利亚和海外养猪业的一个重要问题。目前管理Glassers病的方法使用抗菌药物和疫苗。然而，抗菌药物在难以通过注射以外的方式接种的幼年猪（断奶仔猪）中的有效性有限，并且目前的疫苗仅对疫苗中包含的血清型具有保护作用。我们建议检查对自然感染的免疫反应，并确定潜在的候选疫苗，然后在疫苗试验中进行测试。APAI将致力于开发一种基于DNA的H。副猪。

Novel vaccines and serotyping scheme for Haemophilus parasuis. Glasser's disease, caused by the bacterium Haemophilus parasuis, is a significant problem in Australian and overseas pig industries. Current approaches to the management of Glassers disease utilise antibacterials and also vaccines. However, antibacterials are of limited effectiveness in juvenile pigs (weaners) that are difficult to medicate other than by injection, and current vaccines are only protective against the serotypes included in the vaccine. We propose to examine the immune response to natural infection and identify potential vaccine candidates which will then be tested in vaccine trials. The APAI will focus on developing a DNA-based typing scheme for H. parasuis.