Human environmental test chamber

所要求的最先进的环境试验箱有助于在Ainslie博士的研究中推出新的研究主题-在休息，运动和睡眠期间，在受控的极端气候条件下检查人体生理学。所提出的腔室提供了一种在宽范围内系统地改变温度和/或缺氧程度的手段，允许研究人类对生理应激（例如温度和低氧）的适应和适应不良。所要求的室将允许持续暴露长达两周。从历史上看，野外研究，特别是纵向设计的野外研究，很难控制，因为寒冷的温度，干燥的空气，胃肠道症状的高发病率，食物和液体摄入不足，疲惫和由此产生的心理压力，通常会遇到徒步旅行，并生活在研究地点，所有修改人体生理。 这些问题使得在极端温度下进行纵向研究变得困难;对于任何短期和长期的受控纵向研究来说，一个容易接近和受控的实验室环境是必要的。此外，拟议的温控室也将被用作研究睡眠单元;该室将配备一张床，以允许这些类型的研究。加拿大没有专门用于研究的睡眠实验室;拟议中的设备肯定会为睡眠研究设定新的加拿大标准。 该室将提供探索内源性昼夜节律起搏器在多大程度上有助于先前报道的调节人类脑血流的关键因素的昼夜变化的手段。通过对环境条件的控制，对腔室温度和光照进行精确控制，将能够研究控制脑血流调节中的昼夜节律波动的机制。基础生理学家和临床科学家都对这些机制非常感兴趣。

The requested state-of-the-art environmental test chamber facilitates the launch of new research themes within Dr Ainslie's research - the examination of human physiology in controlled climatic extremes during rest, exercise and sleep. The proposed chamber provides a means to systematically alter temperature and/or the degree of hypoxia over a wide range, allowing the study of human adaptation and maladaptation to physiological stresses such as temperature and low oxygen. The requested chamber will allow for continuous exposures for up to two weeks in duration. Historically, field studies, particularly those of longitudinal design, are difficult to control because cold temperatures, dry air, high incidence of gastrointestinal symptoms, inadequate food and fluid intake, exhaustion and resultant psychological stress typically encountered while hiking to, and living at the study location all modify human physiology. These problems make longitudinal studies at extremes of temperature of oxygen difficult; an easily accessible and controlled laboratory environment is necessary for any short and longer term controlled longitudinal study. Moreover, the proposed temperature controlled chamber will also be used as research sleep unit; the chamber will be fitted with a bed to permit these types of studies. There are no dedicated research-only sleep laboratories in Canada; the proposed equipment would certainly set a new Canadian standard for sleep research. This chamber will provide the means to explore the degree to which the endogenous circadian pacemaker contributes to the previously reported diurnal changes in key factors that regulate brain blood flow in humans. Meticulous control of chamber temperature and light with concomitant control of environment conditions will enable the study of the mechanisms that control circadian rhythm fluctuations in brain blood flow regulation. These mechanisms are of profound interest to basic physiologists and clinical scientists alike.