Radioisotope counting facility

放射性同位素计数设施

• 批准号: 407727-2011
• 负责人: Moon, Thomas
• 金额: $ 5.44万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=472704
• 关键词: Radioisotope; counting; facility

This RTI requests the purchase of two pieces of equipment that will become part of a Radioisotope Counting Facility. The Facility will be part of the Common Laboratory Facilities of the Centre for Advanced Research in Environmental Genomics (CAREG) and will be managed by this unit for the use of the 7 applicants of this proposal, for the other CAREG members (21 to date) and those on the main campus of uOttawa requiring radioisotope counting facilities. Given Canadian legislative requirements, the transportation of radioactive samples is tightly regulated and in the absence of an effective counting facility, the work of at least 35 HQPs supervised by the applicants would be in jeopardy. The request ($74698 including 3.41% HST) is for the purchase of a Tri-Carb 2910TR Liquid Scintillation Counter (LSC) and a WIZARD2 Gamma Counter (GC). The LSC replaces a counter purchased in 2001 which has now been discontinued by its manufacturer; the GC replaces equipment purchased in 1989 which is obsolete and can no longer be repaired. Although technologies continue to improve, the use of radioisotopes for assessing pathway flux, receptor binding and drug discovery remains the 'gold standard'. Both pieces of equipment are heavily used for routine analyses and although they have served the co-applicants well with few major repairs over the years, a catastrophic failure of either piece would be a major blow to the work done by the users.

该 RTI 要求购买两台设备，这些设备将成为放射性同位素计数设施的一部分。该设施将成为环境基因组学高级研究中心 (CAREG) 公共实验室设施的一部分，并将由该单位管理，供本提案的 7 名申请人、其他 CAREG 成员（迄今为止 21 名）以及渥太华大学主校区需要放射性同位素计数设施的成员使用。鉴于加拿大立法要求，放射性样本的运输受到严格监管，在缺乏有效的计数设施的情况下，申请人监督的至少 35 个 HQP 的工作将面临危险。该请求（74698 美元，包括 3.41% HST）用于购买 Tri-Carb 2910TR 液体闪烁计数器 (LSC) 和 WIZARD2 伽玛计数器 (GC)。 LSC 取代了 2001 年购买的计数器，该计数器现已被制造商停产； GC 取代了 1989 年购买的陈旧且无法再维修的设备。尽管技术不断改进，但使用放射性同位素评估通路通量、受体结合和药物发现仍然是“黄金标准”。这两台设备都大量用于常规分析，尽管多年来它们为共同申请人提供了良好的服务，几乎没有进行过重大维修，但其中任何一台设备的灾难性故障都将对用户所做的工作造成重大打击。