Biochemical development of the fetus and neonate and maternal diet

胎儿、新生儿和母亲饮食的生化发育

• 批准号: 3623-2011
• 负责人: Koski, Kristine
• 金额: $ 4.08万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=473744
• 关键词: Biochemical; development; fetus; neonate; maternal

Early nutrition plays an important role in fetal and neonatal growth and development, but surprisingly little research has investigated those nutrients and growth factors that play critical roles in these early biological processes. Historical data points to glucose as the principal metabolic fuel for the developing fetus and fetal glycogen reserves as playing a critical role in preventing neonatal morbidity and mortality including neonatal hypoglycemia. However, we now understand that early perinatal exposure to a complex array of nutrients and growth factors found in amniotic fluid (AF) and in milk, including amino acids, fatty acids, growth hormones, and cytokines, can play an important role in perinatal growth and organ system development and that this complex array of nutrients and growth factors found in both amniotic fluid and milk can contribute to early perinatal programming that can have long lasting biological consequences for development.

早期营养在胎儿和新生儿的生长和发育中起着重要作用，但令人惊讶的是，很少有研究调查在这些早期生物过程中起关键作用的营养素和生长因子。历史数据表明，葡萄糖是发育中胎儿的主要代谢燃料，胎儿糖原储备在预防新生儿发病率和死亡率（包括新生儿低血糖症）方面发挥着关键作用。然而，我们现在了解到，围产期早期暴露于羊水（AF）和乳汁中发现的一系列复杂的营养素和生长因子，包括氨基酸、脂肪酸、生长激素和细胞因子，可以在围产期生长和器官系统发育中发挥重要作用，羊水和乳汁中发现的这种复杂的营养素和生长因子可以有助于围产期早期规划，会对发育产生长期的生物学影响。