Phytochemical and ethnobotanical discovery of endemic American plants

美洲特有植物的植物化学和民族植物学发现

• 批准号: 7174-2010
• 负责人: Arnason, John
• 金额: $ 4.22万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=474207
• 关键词: Phytochemical; ethnobotanical; discovery; endemic; American

The purpose of this research is to study traditionally used plants scientifically in order to understand the nature of the phytochemical substances that makes them active. There is some urgency due to the rapidly disappearing knowledge of indigenous healers.We have a longstanding collaboration with Maya curanderos in Central America and Cree/Inuit healers in Northern Canada with whom we will work to document medicinal plant use for infections and neurodegenerative diseases, then test them in relevent lab assays. We are particularly interested in determining if antiinfective plants can inhibit bacterial biofilm formation, an emerging problem in medicine and industry for which we have few solutions. Similarly, we will assess if some traditionally used plants have the capacity to prevent neurodegerneration in standardized lab assays. The active plants and other plants that we previously identified as active in epilepsy and anxiety assays will be extracted for the purpose of isolation and identification of the active principles. Some of the more important plants that belong to the important blueberry-cranberry genus, Vaccinium, or the tropical pepper genus, Piper are being thoroughly investigated for phytochemical substances by advanced chemical instrumentation methods, NMR metabolomics and HPLC/MS/MS. The program will train 5 graduate students, contribute to our understanding of ethnobotany and potentially lead to new treatments and useful natural health products.

这项研究的目的是科学地研究传统使用的植物，以了解使它们活跃的植物化学物质的性质。由于土著治疗师的知识正在迅速消失，因此有一些紧迫性。我们与中美洲的玛雅库兰德罗斯和加拿大北方的克里人/因纽特人治疗师有着长期的合作，我们将与他们合作记录药用植物用于感染和神经退行性疾病，然后在相关的实验室检测中进行测试。我们特别感兴趣的是确定抗感染植物是否可以抑制细菌生物膜的形成，这是医学和工业中的一个新问题，我们几乎没有解决方案。同样，我们将评估一些传统使用的植物是否有能力在标准化的实验室检测中预防神经退化。将提取我们先前在癫痫和焦虑测定中鉴定为活性的活性植物和其他植物，以分离和鉴定活性成分。一些更重要的植物，属于重要的蓝莓，蔓越莓属，越桔，或热带胡椒属，胡椒正在彻底调查植物化学物质的先进化学仪器方法，NMR代谢组学和HPLC/MS/MS该计划将培养5名研究生，有助于我们对民族植物学的理解，并可能导致新的治疗方法和有用的天然保健产品。