Production, chemistry and pharmacology of botanical anxiolytics and cortisol lowering agents for animal health market

用于动物保健市场的植物抗焦虑药和皮质醇降低剂的生产、化学和药理学

• 批准号: 463303-2014
• 负责人: Arnason, John
• 金额: $ 3.5万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=558351
• 关键词: Production; chemistry; pharmacology; botanical; anxiolytics

Based on phytochemical discovery research, our team has successfully launched the Sin SustoTM anxiolytic product, an allopathic natural health product for Vet application as a calming and cortisol lowering agent in dogs. Feedback from veterinarians and our own data, indicates that new research is needed to answer aspects of quality assurance (agronomic and phytochemical standardization) safety evaluation (pharmacokinetics, pharmacodynamics, drug interactions) and mode of action ( pharmacology). The discovery of the cortisol lowering activity of the active principle, betulinic acid, provides a lead compound for semi synthesis of a pipeline of potential pharmaceuticals for evaluation and application in Cushings disease and metabolic syndrome.

基于植物化学发现研究，我们的团队成功推出了Sin SustoTM抗焦虑产品，这是一种用于兽医应用的对抗疗法天然健康产品，可作为犬的镇静剂和皮质醇降低剂。兽医的反馈和我们自己的数据表明，需要进行新的研究来回答质量保证方面的问题（农艺和植物化学标准化） 安全性评价（药代动力学、药效学、药物相互作用）和作用方式（药理学）。活性成分桦木酸的皮质醇降低活性的发现，为潜在药物的半合成提供了先导化合物，用于评估和应用于库欣病和代谢综合征。