Analysis of the Role of Snapin in the Regulation of SNARE Complex Assembly

Snapin在SNARE复合体组装调控中的作用分析

• 批准号: ARC : DP0208625
• 负责人: Dr Tony Rowe
• 金额: $ 14.1万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/analysis-role-snapin-complex-assembly/65633
• 关键词: Analysis; Role; Snapin; Regulation; SNARE

Analysis of the Role of Snapin in the Regulation of SNARE Complex Assembly. The aims of the proposed studies are to investigate the role played by a protein, snapin in the trafficking of membranes and cargo proteins between different compartments inside mammalian cells. Membrane trafficking is a fundamental cellular process that requires a family of related molecules termed SNARES. We have recently discovered that snapin interacts with certain members of the SNARE family, implying a critical role in membrane trafficking. The proposed studies will provide important new insights into the molecular mechanisms underlying the function of both snapin and SNAREs, and membrane trafficking in general.

Snapin在SNARE复合物组装调控中的作用分析。拟议研究的目的是研究一种蛋白质，snapin在哺乳动物细胞内不同隔间之间的膜和货物蛋白运输中所起的作用。膜运输是一个基本的细胞过程，它需要一个称为SNARES的相关分子家族。我们最近发现，snapin与SNARE家族的某些成员相互作用，这意味着在膜运输中起着关键作用。拟议的研究将为snapin和SNAREs功能的分子机制以及一般的膜运输提供重要的新见解。