Synthetic and mechanistic studies of formation of novel beta-lactams

新型β-内酰胺的合成和形成机理研究

• 批准号: 9504-2009
• 负责人: Tidwell, Thomas
• 金额: $ 1.97万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=474564
• 关键词: Synthetic; mechanistic; studies; formation; novel

Studies of the formation of beta-lactams, a vital part of penicillins and related antibiotics, will be carried out. The mechanism of formation of these materials by ketene-imine [2+2] cycloadditions will be examined, including measurements of the rates of reaction depending upon the substituents on both the ketenes and the imines, determination of kinetic isotope effects, and the direct observation of zwitterionic reaction intermediates.

将对青霉素和相关抗生素的重要组成部分β-内酰胺的形成进行研究。这些材料的形成机理由烯酮亚胺[2+2]环加成将被检查，包括测量的反应速率取决于取代基上的烯酮和亚胺，动力学同位素效应的测定，和两性离子反应中间体的直接观察。