Australian Laureate Fellowships - Grant ID: FL210100071

澳大利亚获奖者奖学金 - 拨款 ID：FL210100071

• 批准号: ARC : FL210100071
• 金额: $ 324.6万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Australian Laureate Fellowships
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://researchdata.edu.au/australian-laureate-fellowships-id-fl210100071/1782153
• 关键词: Australian; Laureate; Fellowships; Grant; ID

“L-form” bacteria: basic science, antibiotics, evolution and biotechnology. This Fellowship addresses key gaps in knowledge about cell wall deficient bacteria called L-forms: an altered state of bacteria with intriguing properties both structurally and functionally. The main aims of the research program are to improve our understanding of the basic biology of L-forms and employ them as tools in several important ways: for understanding the mechanisms of cell wall synthesis and how antibiotics work, as models for early steps in the evolution of cellular life, and as a significant new platform for the production of proteins and fine chemicals. Outcomes and benefits include improved understanding of how to generate new antibiotics, and the development of new platforms for Australian biotechnology and biocommerce.

“l型细菌：基础科学、抗生素、进化与生物技术。该奖学金解决了关于细胞壁缺陷细菌（称为L型）知识的关键空白：细菌的一种改变状态，具有结构和功能上的有趣特性。该研究计划的主要目的是提高我们对L型的基础生物学的理解，并以几种重要的方式将它们作为工具：了解细胞壁合成的机制以及抗生素如何工作，作为细胞生命进化早期步骤的模型，以及作为生产蛋白质和精细化学品的重要新平台。成果和好处包括提高对如何产生新抗生素的理解，以及为澳大利亚生物技术和生物商务开发新平台。