Characterization of erythroid differentiation related factor (EDRF): a novel a-globin binding protein

红系分化相关因子 (EDRF) 的表征：一种新型 a-珠蛋白结合蛋白

• 批准号: ARC : DP0342760
• 负责人: Joel Mackay
• 金额: $ 57.9万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterization-erythroid-differentiation-binding-protein/69757
• 关键词: Characterization; erythroid; differentiation; related; factor

Characterization of erythroid differentiation related factor (EDRF): a novel a-globin binding protein. Hemoglobin, a four-subunit protein comprising two alpha and two beta polypeptide chains, is the essential oxygen transporter found in all mammals. Problems with the synthesis of hemoglobin can give rise to a range of common and serious human disorders, including thalassaemia and anemia. We have discovered a protein, EDRF, that appears to interact directly with alpha-globin (but not beta-globin) and to play a role in the regulation of hemoglobin production. We now seek to understand the nature of this interaction at a molecular level and mechanistic level.

红细胞分化相关因子（EDRF）的表征：一种新的a-球蛋白结合蛋白。血红蛋白是一种由两个α和β多肽链组成的四亚基蛋白，是所有哺乳动物体内必不可少的氧气转运蛋白。血红蛋白合成的问题可引起一系列常见和严重的人类疾病，包括地中海贫血和贫血。我们发现了一种名为EDRF的蛋白质，它似乎与α -珠蛋白（而不是β -珠蛋白）直接相互作用，并在血红蛋白生成的调节中发挥作用。我们现在试图在分子水平和机械水平上理解这种相互作用的本质。