Behind the barrier: using mathematics to understand the neuro-immune system

障碍背后：用数学来理解神经免疫系统

• 批准号: DE240100650
• 负责人: Dr Adrianne Jenner
• 金额: $ 30.71万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-06-01 至 2027-06-01
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE240100650
• 关键词: Behind; barrier; using; mathematics; understand

This project aims to develop new mathematical methods to study healthy immune cell regulation in the brain and movement across the Blood Brain Barrier. The project expects to develop novel deterministic and stochastic mathematics that captures the stochasticity of immune cells in the Central Nervous System (brain and spine) and form the foundation of a new field of mathematical research: mathematical neuroimmunology. Expected benefits of this project include new mathematical tools, biological insight, and strong interdisciplinary collaborations. From this project, Australia will be placed at the forefront of mathematical research in neuroimmunology, and there will be a complete understanding of homeostasis of the neuro-immune system.

该项目旨在开发新的数学方法来研究大脑中健康的免疫细胞调节和穿过血脑屏障的运动。该项目预计将开发新的确定性和随机数学，捕获中枢神经系统（大脑和脊柱）中免疫细胞的随机性，并形成数学研究新领域的基础：数学神经免疫学。该项目的预期收益包括新的数学工具，生物学洞察力和强大的跨学科合作。通过这个项目，澳大利亚将处于神经免疫学数学研究的最前沿，并将对神经免疫系统的稳态有一个完整的了解。