Synthesis of substrate analogues for probing catalytic mechanisms and specificity of enzymes involved in the metabolism of plant polysaccharides

底物类似物的合成用于探测植物多糖代谢中酶的催化机制和特异性

• 批准号: ARC : LX0239960
• 负责人: Dr Hugues Driguez
• 金额: $ 3.57万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Linkage - International
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/synthesis-substrate-analogues-plant-polysaccharides/62891
• 关键词: Synthesis; substrate; analogues; probing; catalytic

Synthesis of substrate analogues for probing catalytic mechanisms and specificity of enzymes involved in the metabolism of plant polysaccharides. The project is aimed at strengthening collaborations between research groups in Adelaide and France, with the specific objective of synthesizing substrate analogues as probes of enzymatic mechanisms and substrate specificity in polysaccharide hydrolases and synthases of barley. The chemical expertise resides in France, while the enzymatic work will be conducted largely in Australia. Exchange of research staff, particularly at the postgraduate student and research associate levels, is considered essential to capture the benefits of the complementary expertise and to extend an existing international collaboration. The target enzymes are of central importance in cell wall metabolism during development of higher plants.

底物类似物的合成，用于探索植物多糖代谢相关酶的催化机制和特异性。该项目旨在加强阿德莱德和法国研究小组之间的合作，具体目标是合成底物类似物，作为大麦多糖水解酶和淀粉酶的酶机制和底物特异性的探针。化学专业知识在法国，而酶的工作将主要在澳大利亚进行。研究人员的交流，特别是研究生和研究助理人员的交流，被认为是获取互补专门知识的好处和扩大现有国际合作的关键。目的酶在高等植物发育过程中的细胞壁代谢中具有重要作用。