Synthetic Molybdenum Enzymes

合成钼酶。该项目的目的是生产合成钼（钼）酶，小分子共享的结构和功能属性与至关重要的dopterin？钼酶。这些无处不在的酶对于植物和动物健康，涉及碳，氮和硫的自然循环以及全球气候控制和大气反射率至关重要;因此，它们对商业，环境和社会产生了重大影响。这项研究将提供迫切需要的见解的基本莫？硫化学的酶活性位点，并告知努力减少酶功能障碍的负面影响和新的商业催化剂的设计。

Synthetic Molybdenum Enzymes. This project aims to produce synthetic molybdenum (Mo) enzymes, small molecules that share structural and functional attributes with the crucially important molybdopterin?Mo enzymes. These ubiquitous enzymes are essential for plant and animal health, natural cycles involving carbon, nitrogen and sulfur, and global climate control and atmospheric albedo (reflectance); consequently, they impact heavily on commerce, the environment and society. The study will provide urgently needed insights into the fundamental Mo?sulfur chemistry of the enzyme active sites and inform efforts to reduce the negative impacts of enzyme dysfunction and the design of new commercial catalysts.