The biosynthesis of bioactive cyclic peptides

生物活性环肽的生物合成

• 批准号: 228861-2010
• 负责人: Covello, Patrick
• 金额: $ 1.63万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=478736
• 关键词: biosynthesis; bioactive; cyclic; peptides

In most cases, the proteins in living things consist of strings of amino acids which are linear. In some cases, especially for small proteins or peptides, the amino acids form a circle, giving rise to what are called cyclic peptides. Cyclic peptides are relatively stable in harsh chemical environments and in living things. They often have interesting pharmacological properties. For example, cyclosporin A is a fungal cyclic peptide with immunosuppressant activity and is used for organ transplantation. Many plants in the Caryophyllaceae family, which includes carnation, accumulate cyclic peptides. The cowcockle plant (Saponaria vaccaria), which will be studied in the project, has cyclic peptides with properties that may be useful in controlling blood pressure.

在大多数情况下，生物中的蛋白质由线性氨基酸链组成。在某些情况下，特别是对于小的蛋白质或肽，氨基酸形成一个环，产生所谓的环肽。环肽在恶劣的化学环境和生物中相对稳定。它们通常具有有趣的药理学特性。例如，环孢菌素A是一种具有免疫抑制活性的真菌环肽，用于器官移植。康乃馨科中的许多植物，包括康乃馨，积累环肽。将在该项目中进行研究的cowcockle植物（Saponaria vagaria）含有环肽，其特性可能有助于控制血压。