The biosynthesis of bioactive cyclic peptides

生物活性环肽的生物合成

• 批准号: 228861-2010
• 负责人: Covello, Patrick
• 金额: $ 1.63万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=524224
• 关键词: biosynthesis; bioactive; cyclic; peptides

In most cases, the proteins in living things consist of strings of amino acids which are linear. In some cases, especially for small proteins or peptides, the amino acids form a circle, giving rise to what are called cyclic peptides. Cyclic peptides are relatively stable in harsh chemical environments and in living things. They often have interesting pharmacological properties. For example, cyclosporin A is a fungal cyclic peptide with immunosuppressant activity and is used for organ transplantation. Many plants in the Caryophyllaceae family, which includes carnation, accumulate cyclic peptides. The cowcockle plant (Saponaria vaccaria), which will be studied in the project, has cyclic peptides with properties that may be useful in controlling blood pressure.

在大多数情况下，生物体内的蛋白质是由一串串线性的氨基酸组成的。在某些情况下，特别是对于小的蛋白质或肽，氨基酸形成一个圆圈，产生所谓的环状肽。环肽在恶劣的化学环境和生物体内相对稳定。它们通常具有有趣的药理特性。例如，环孢素A是一种具有免疫抑制活性的真菌环肽，用于器官移植。石竹科的许多植物，包括康乃馨，积累环状肽。该项目将研究的牛蒡植物（Saponaria vaccaria）含有可用于控制血压的环状肽。