The role of snare-mediated membrane traffic in cell adhesion

圈套器介导的膜运输在细胞粘附中的作用

• 批准号: 239122-2007
• 负责人: Coppolino, Marc
• 金额: $ 3.06万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=479101
• 关键词: role; snare; mediated; membrane; traffic

Cell adhesion is a complex process that plays a fundamental role in the growth and differentiation of cells in multicellular organisms. In particular, cell adhesion has profound influence over the survival of dells within tissues and organs and can also significantly impact many pathological conditions. Cell adhesion is the process by which cells attach and spread on protein-based structures outside the cell (the extracellular matrix). Such interactions affect cell shape, intracellular structures and biochemical reactions and gene expression. The long-term goals of my research are to examine the intracellular, molecular machinery that specifically regulates cell adhesion. In doing this, I intend to establish a research program that will contribute to the basic understanding of these biological functions within cells.

细胞黏附是一个复杂的过程，对多细胞生物体中细胞的生长和分化起着基础性的作用。特别是，细胞黏附对组织和器官内的Dell的生存有深远的影响，也可以显著地影响许多病理条件。细胞黏附是细胞在细胞外基于蛋白质的结构(细胞外基质)上附着和扩散的过程。这种相互作用影响细胞形状、细胞内结构、生化反应和基因表达。我这项研究的长期目标是研究细胞内的分子机制，这种机制专门调节细胞黏附。在这样做的过程中，我打算建立一个研究计划，有助于对细胞内这些生物功能的基本理解。