Role of SNARE-mediated Trafficking in Cell-ECM Interaction

SNARE 介导的运输在细胞-ECM 相互作用中的作用

• 批准号: RGPIN-2017-05199
• 负责人: Coppolino, Marc
• 金额: $ 1.89万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629408
• 关键词: Role; SNARE; mediated; Trafficking; Cell

Dynamic cell-extracellular matrix (ECM) interactions, including cell adhesion and migration, require binding of ECM proteins by integrins and subsequent intracellular biochemical signalling. Integrin function is dependent on the intracellular trafficking of integrins and associated proteins, and this traffic is mediated by membrane-anchored proteins called SNAREs (

动态细胞-细胞外基质（ECM）相互作用，包括细胞粘附和迁移，需要整合素结合ECM蛋白和随后的细胞内生化信号。整合素的功能依赖于整合素和相关蛋白的细胞内运输，这种运输是由称为SNAREs的膜锚定蛋白介导的(