The sulfate anion transporter gene, Sat1: physiology, regulation and developmental expression.

硫酸根阴离子转运蛋白基因 Sat1：生理学、调节和发育表达。

• 批准号: ARC : DP0208082
• 负责人: Dr Daniel Markovich
• 金额: $ 14.1万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/the-sulfate-anion-developmental-expression/68772
• 关键词: sulfate; anion; transporter; gene; Sat1

The sulfate anion transporter gene, Sat1: physiology, regulation and developmental expression. Sulfate is an essential nutrient for cell growth and survival. The kidneys and liver help regulate sulfate levels in the body, by yet unknown mechanisms. Recently, we cloned a gene, Sat1, expressed in mouse liver and kidneys, which may be responsible for body sulfate maintenance. In this study, we will determine the physiological importance of Sat1 in cell growth/survival and in controlling body sulfate levels. We will generate and characterise a Sat1 lacking mouse, study its expression during development and its effects on other genes. We will elucidate how body sulfate levels are maintained and its importance in cell growth/development.

硫酸根阴离子转运蛋白基因 Sat1：生理学、调节和发育表达。硫酸盐是细胞生长和存活的必需营养素。肾脏和肝脏通过未知的机制帮助调节体内的硫酸盐水平。最近，我们克隆了一个在小鼠肝脏和肾脏中表达的基因 Sat1，该基因可能负责体内硫酸盐的维持。在这项研究中，我们将确定 Sat1 在细胞生长/存活和控制体内硫酸盐水平方面的生理重要性。我们将生成并表征缺乏 Sat1 的小鼠，研究其在发育过程中的表达及其对其他基因的影响。我们将阐明如何维持体内硫酸盐水平及其在细胞生长/发育中的重要性。