The sulfate anion transporter gene, Sat1: physiology, regulation and developmental expression.

硫酸盐阴离子转运蛋白基因Sat1：生理、调控和发育表达。硫酸盐是细胞生长和生存所必需的营养物质。肾脏和肝脏通过未知的机制帮助调节体内的硫酸盐水平。最近，我们克隆了一个在小鼠肝脏和肾脏中表达的基因Sat1，该基因可能负责体内硫酸盐的维持。在这项研究中，我们将确定Sat1在细胞生长/存活和控制体内硫酸盐水平方面的生理重要性。我们将产生并鉴定缺乏Sat1的小鼠，研究其在发育过程中的表达及其对其他基因的影响。我们将阐明如何维持体内硫酸盐水平及其在细胞生长/发育中的重要性。

The sulfate anion transporter gene, Sat1: physiology, regulation and developmental expression. Sulfate is an essential nutrient for cell growth and survival. The kidneys and liver help regulate sulfate levels in the body, by yet unknown mechanisms. Recently, we cloned a gene, Sat1, expressed in mouse liver and kidneys, which may be responsible for body sulfate maintenance. In this study, we will determine the physiological importance of Sat1 in cell growth/survival and in controlling body sulfate levels. We will generate and characterise a Sat1 lacking mouse, study its expression during development and its effects on other genes. We will elucidate how body sulfate levels are maintained and its importance in cell growth/development.