Evolutionary biology of deleterious mutations and sex

有害突变和性别的进化生物学

• 批准号: 288256-2010
• 负责人: Agrawal, Aneil
• 金额: $ 2.91万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=480450
• 关键词: Evolutionary; biology; deleterious; mutations; sex

The ubiquity of sex and recombination across disparate forms of biological life indicate that the selective pressures favouring genetic exchange are powerful and widespread. Understanding this source of selection is not only important to basic science but may allow for improved management of biological resources (i.e., agriculture, fisheries, forestry, conservation). However, the ultimate reasons for sex and recombination have been elusive. Although there has been considerable progress in understanding the conceptual issues underlying this classic problem, many theoretical and empirical questions remain. The proposed research outlines several projects designed to illuminate the importance of different factors affecting the evolution of sex. Specifically, theory will be developed to evaluate how different sources of genetic variation (e.g., deleterious mutation, spatial heterogeneity in selection, host-parasite coevolution) contribute to selection for sex. Empirically, we will test how sex and recombination affect the mean and variance in fitness under different experimental conditions.

性和重组在不同生物形式中的普遍存在表明，有利于基因交换的选择压力是强大而广泛的。了解这种选择的来源不仅对基础科学很重要，而且可以改善生物资源的管理（即，农业、渔业、林业、养护）。 然而，性别和重组的最终原因一直难以捉摸。 虽然在理解这一经典问题背后的概念问题方面取得了相当大的进展，但仍然存在许多理论和经验问题。 拟议的研究概述了几个项目，旨在阐明影响性别进化的不同因素的重要性。 具体来说，将发展理论来评估不同来源的遗传变异（例如，有害突变、选择中的空间异质性、宿主-寄生虫共同进化）有助于性别选择。 从经验上讲，我们将测试性别和重组如何在不同的实验条件下影响适应度的均值和方差。