The role of longin-SNAREs in proteins sorting and membrane fusion

longin-SNARE 在蛋白质分选和膜融合中的作用

• 批准号: 327237-2009
• 负责人: Eitzen, Gary
• 金额: $ 2.33万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=481639
• 关键词: role; longin; SNAREs; proteins; sorting

Exocytosis and membrane fusion are mechanisms used by all cells to maintain their survival and perform their unique functions. This process involves the transport of intracellular vesicles to the cell periphery where they dock and undergo membrane fusion, resulting in the release of their contents extracellularly. For example, white blood cells can attack and degrade invading pathogens by releasing intracellular enzymes and chemical mediators of inflammation. Since these enzymes and chemicals are toxic they are sequestered in intracellular packages called vesicles and only released by exocytosis and membrane fusion at the cell periphery when invading pathogens are sensed.

胞吐作用和膜融合是所有细胞用来维持其存活和执行其独特功能的机制。 该过程涉及胞内囊泡运输到细胞外周，在那里它们停靠并进行膜融合，导致其内容物释放到细胞外。例如，白色血细胞可以通过释放细胞内酶和炎症的化学介质来攻击和降解入侵的病原体。 由于这些酶和化学物质是有毒的，它们被隔离在称为囊泡的细胞内包装中，并且只有当入侵的病原体被感知时才通过胞吐作用和细胞周边的膜融合释放。