Role integrin receptors in recognition of pathogen-associated molecular patterns and innate immunity

整合素受体在识别病原体相关分子模式和先天免疫中的作用

• 批准号: 327238-2007
• 负责人: Ulanova, Marina
• 金额: $ 2.04万
• 依托单位: Lakehead University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=481640
• 关键词: Role; integrin; receptors; recognition; pathogen

The innate immunity is an ancient mechanism serving to rapidly detect invading microorganisms and to initiate host defense. The body has a wide array of cellular receptors to recognize "the danger signals", i.e. some molecular structures typical for various microorganisms. Such recognition will signal the body that there is a danger of a damage or disease. I hypothesize that integrins which are present on the surface of epithelial cells in the lungs serve as receptors to recognize potentially harmful structures, for example, products by pathogenic bacteria. Integrins can then initiate signaling mechanisms that will modify cellular functions to ensure the proper response to the invaders. In this project, I plan to investigate molecular mechanisms of integrin function as pattern recognition receptors. I intend to understand how integrins contribute to the innate immune defense of the body, in particular, how they can help to fight some diseases caused by pathogenic bacteria. The results of my studies will be important for better understanding of mechanisms of innate immunity which are fundamental in host defense against pathogenic microorganisms.

先天免疫是一种古老的机制，用于快速检测入侵的微生物并启动宿主防御。身体有一系列细胞受体来识别“危险信号”，即各种微生物的典型分子结构。这种识别将向身体发出信号，表明存在损伤或疾病的危险。我推测，整合素是目前在肺上皮细胞表面作为受体，以识别潜在的有害结构，例如，产品的病原菌。然后整合素可以启动信号传导机制，改变细胞功能，以确保对入侵者的适当反应。在这个项目中，我计划研究整合素作为模式识别受体的分子机制。我打算了解整合素如何有助于身体的先天免疫防御，特别是，它们如何帮助对抗病原菌引起的一些疾病。我的研究结果将是重要的，更好地了解机制的先天免疫，这是根本的宿主防御病原微生物。