Modeling the evolutionary and epidemiological patterns of infectious diseases

模拟传染病的进化和流行病学模式

• 批准号: 341616-2007
• 负责人: Ma, Junling
• 金额: $ 1.09万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=482194
• 关键词: Modeling; evolutionary; epidemiological; patterns; infectious

The proposed research program concentrates on modeling the evolutionary and epidemiological patterns of infectious diseases, with an emphasis on influenza. Influenza is a major cause of human morbidity and mortality. Influenza viruses undergo rapid mutations to evade human immune system. Drastic genetic changes occur from time to time. Influenza pandemics (e.g. in 1918, 1957 and 1968) were caused by these drastic changes. Hence, both influenza pandemic planning and inter-pandemic control have become important public health concerns.

拟议的研究计划集中在模拟传染病的进化和流行病学模式，重点是流感。流感是人类发病和死亡的主要原因。流感病毒经过快速突变以逃避人类免疫系统。剧烈的遗传变化时有发生。流感大流行（如1918年、1957年和1968年）就是由这些剧烈变化引起的。因此，流感大流行的规划和大流行之间的控制已成为重要的公共卫生问题。