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Changes in synaptic plasticity by A-beta and the APP intracellular domain (AICD)

Changes in synaptic plasticity by A-beta and the APP intracellular domain (AICD)
A-β 和 APP 胞内结构域 (AICD) 改变突触可塑性
批准号：
183402
负责人：
Boehm Jannic
金额：
$7.29万
依托单位：
Universit de Montral
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2008
资助国家：
加拿大
项目状态：
已结题
起止时间：
2008-09-01 至 2009-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=183402&lang=en
关键词：
Alzheimer'S Disease Calcium Imaging Electrophysiology Hippocampal Slice Cultures Synaptic Plasticity Two-Photon Imaging

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中文摘要
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英文摘要
Alzheimer's disease (AD), a progressive neurodegenerative disorder, is the most common form of dementia in the elderly. The prime candidate for the cause of Alzheimer's disease is the peptide beta-amyloid (A-beta), which is formed by biochemical processin
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The amyloid precursor protein intracellular domain is an effector molecule of metaplasticity - implications for the regulation of synaptic plasticity in Alzheimer disease.
The amyloid precursor protein intracellular domain is an effector molecule of metaplasticity - implications for the regulation of synaptic plasticity in Alzheimer disease.
Regulation of synaptic plasticity by the amyloid precursor protein (APP)
  • 批准号：
    191173
  • 项目类别：
    Operating Grants
  • 资助金额：
    $49.72万
  • 财政年份：
    2009
  • 负责人：
    Boehm Jannic
  • 依托单位：
    Universit de Montral
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