Chemomechanical dissoultion of bioactive glass

生物活性玻璃的化学机械溶解

• 批准号: 355540-2008
• 负责人: Nychka, John
• 金额: $ 1.68万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=482740
• 关键词: Chemomechanical; dissoultion; bioactive; glass

Structural materials used in biomedical implants are rarely in a stress or strain free state; residual manufacturing stresses and in service stresses may exist. Interestingly, residual stress can have a direct impact on how biomedical devices perform, and because residual stress can affect the mechanical behavior of all materials, understanding the relationship between bioactivity and mechanical properties is paramount in further development of biomedical materials. We have found that residual stresses alter the dissolution behaviour of bioactive glasses which are used for bone regrowth and repair in dental and orthopedic surgery. We are in the process of developing a model to describe such a phenomenon and our proposed research will attempt to further understand the relationship between mechanical stress and dissolution behaviour (called the mechanochemical effect), but also investigate how the mechanical behaviour of the material is altered by reaction with the biological environment (called the chemomechanical effect). Our underlying goal is to assess the feasibility of processing biomedical materials through local adjustment of residual stresses before implantation in order to create gradients of bioactivity on implants to prevent against premature failure.

生物医学植入物中使用的结构材料很少处于无应力或无应变状态;可能存在残余制造应力和使用应力。有趣的是，残余应力可以直接影响生物医学器件的性能，并且由于残余应力可以影响所有材料的机械行为，因此了解生物活性和机械性能之间的关系对于生物医学材料的进一步开发至关重要。我们已经发现，残余应力改变了生物活性玻璃的溶解行为，这些玻璃用于牙科和整形外科手术中的骨再生和修复。我们正在开发一个模型来描述这种现象，我们提出的研究将试图进一步了解机械应力和溶解行为之间的关系（称为机械化学效应），但也研究材料的机械行为如何通过与生物环境的反应而改变（称为化学机械效应）。 我们的基本目标是评估通过植入前局部调整残余应力来处理生物医学材料的可行性，以便在植入物上产生生物活性梯度，以防止过早失效。