Nature and morphogenesis of the intracellular compartments established by commensal and pathogenic bacteria in dendritic cells

树突状细胞中共生菌和病原菌建立的细胞内区室的性质和形态发生

• 批准号: 355655-2008
• 负责人: Terebiznik, Mauricio
• 金额: $ 2.55万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=482804
• 关键词: Nature; morphogenesis; intracellular; compartments; established

Dendritic cells (DCs) are a key component of the immune system. These cells sample the gut epithelium engulfing pathogenic bacteria into intracellular compartments known as phagosomes. Inside phagosomes bacteria are killed and digested. Distinctive bacterial components, like protein fragments, are then presented by DCs to the lymphocytes. This action activates lymphocytes, which will fight the bacterial infection.

树突状细胞（DC）是免疫系统的关键组成部分。这些细胞将肠道上皮细胞的样本吞入细胞内的病原菌区室称为吞噬体。在吞噬体内，细菌被杀死并被消化。独特的细菌成分，如蛋白质片段，然后由DC呈递给淋巴细胞。这个动作激活淋巴细胞，这将打击细菌感染。