Mediators shaping CD8 T cell activation and functions

调节 CD8 T 细胞激活和功能的介质

• 批准号: 355722-2008
• 负责人: Arbour, Nathalie
• 金额: $ 2.19万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=482833
• 关键词: Mediators; shaping; CD8; cell; activation

Our immune system is composed of numerous cells and molecules that are patrolling from our blood stream to all organs. When a danger is detected in one organ these cells and molecules enter the targeted organ and start a whole cascade of events to get ride of the danger: be a potential tumor or a microbe. Amongst the white blood cells circulating in human blood, a particular cell type named CD8 T cell plays a key role in controlling microbes. The proposed research program deals with CD8 T cells and aims to determine how these cells are influenced by environmental and intrinsic factors. The factors that are studied include soluble molecules (free-floating molecules), molecules on the surface of CD8 T cells as well as molecules inside these cells. In order to complete these studies various methods will be exploited from tissue culture, molecular biology and flow cytometry. Graduate students participating to this program will gain a diversified training in basic immunology, biology and complex data analysis. The final goal is to elucidate the molecular mechanisms from surface interactions to intracellular signaling cascades involved in shaping CD8 T cell functions.

我们的免疫系统是由大量的细胞和分子组成的，它们从我们的血液流动到所有器官。当在一个器官中检测到危险时，这些细胞和分子进入目标器官并启动一系列事件以摆脱危险：成为潜在的肿瘤或微生物。在人类血液中循环的白色血细胞中，一种名为CD8 T细胞的特殊细胞类型在控制微生物方面起着关键作用。拟议的研究计划涉及CD8 T细胞，旨在确定这些细胞如何受到环境和内在因素的影响。研究的因素包括可溶性分子（自由浮动分子），CD8 T细胞表面的分子以及这些细胞内部的分子。为了完成这些研究，将利用组织培养、分子生物学和流式细胞术的各种方法。参加该计划的研究生将获得基础免疫学，生物学和复杂数据分析方面的多元化培训。 最终目标是阐明从表面相互作用到参与塑造CD8 T细胞功能的细胞内信号级联的分子机制。