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Analysis of c-Kit and insulin receptor signaling interactions in regulating pancreatic beta-cell function and islet vasculature

Analysis of c-Kit and insulin receptor signaling interactions in regulating pancreatic beta-cell function and islet vasculature
c-Kit 和胰岛素受体信号相互作用在调节胰腺 β 细胞功能和胰岛脉管系统中的分析
批准号：
238283
负责人：
Wang Rennian
金额：
$51.22万
依托单位：
University of Western Ontario
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2011
资助国家：
加拿大
项目状态：
已结题
起止时间：
2011-09-01 至 2016-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=238283&lang=en
关键词：
Beta-Cell Specific C-Kit Transgenic Mice C-Kit Wv Mutation Mice Cross-Talk Between C-Kit And Insulin Receptors High-Fat Diet Diabetes Insulin Receptor/Insulin Receptor Substrates Islet Biology Islet Vasculature Pi3k/Akt/Gsk3b Signaling Pathway Ste

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中文摘要
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英文摘要
Diabetes is one of the most common metabolic diseases, affecting over 2 million Canadians. It is associated with a multitude of complications (vascular, limb, kidney, eye), leading to considerable morbidity and a major medical as well as financial burden
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Studies of the functional role of pancreatic stellate cells (PaSCs) during islet differentiation, regeneration and diabetes.
  • 批准号：
    356263
  • 项目类别：
    Operating Grants
  • 资助金额：
    $51.83万
  • 财政年份：
    2016
  • 负责人：
    Wang Rennian
  • 依托单位：
    University of Western Ontario
Role of MENIN in the Developing Human Pancreas & Diabetes
  • 批准号：
    182754
  • 项目类别：
    Operating Grants
  • 资助金额：
    $10.93万
  • 财政年份：
    2009
  • 负责人：
    Wang Rennian
  • 依托单位：
    University of Western Ontario