Analysis of c-Kit and insulin receptor signaling interactions in regulating pancreatic beta-cell function and islet vasculature

c-Kit 和胰岛素受体信号相互作用在调节胰腺 β 细胞功能和胰岛脉管系统中的分析

• 批准号: 238283
• 负责人: Wang Rennian
• 金额: $ 51.22万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-09-01 至 2016-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=238283&lang=en
• 关键词: Beta-Cell Specific C-Kit Transgenic Mice; C-Kit Wv Mutation Mice; Cross-Talk Between C-Kit And Insulin Receptors; High-Fat Diet Diabetes; Insulin Receptor/Insulin Receptor Substrates; Islet Biology; Islet Vasculature; Pi3k/Akt/Gsk3b Signaling Pathway; Ste

Diabetes is one of the most common metabolic diseases, affecting over 2 million Canadians. It is associated with a multitude of complications (vascular, limb, kidney, eye), leading to considerable morbidity and a major medical as well as financial burden

糖尿病是最常见的代谢性疾病之一，影响着200多万加拿大人。它与多种并发症(血管、四肢、肾脏、眼睛)有关，导致相当大的发病率以及重大的医疗和经济负担。