Studies of the functional role of pancreatic stellate cells (PaSCs) during islet differentiation, regeneration and diabetes.

研究胰腺星状细胞 (PaSC) 在胰岛分化、再生和糖尿病过程中的功能作用。

• 批准号: 356263
• 负责人: Wang Rennian
• 金额: $ 51.83万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-10-01 至 2021-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=356263&lang=en
• 关键词: Diabetic Mouse Models; Human Fetal Pancreas; Islet Cell Differentiation; Islet Regeneration; Islet-Epithelial Cell Cluster Coculture; Pancreatic Duct Ligation; Pancreatic Stellate Cells; Pancreatic Stellate Cells Inhibitor

A major problem for people with diabetes is the loss of insulin-producing beta-cells in the pancreas. Repopulating beta-cells requires a thorough analysis of the factors that regulate their growth and maintain their function. One important cell type near

糖尿病患者的一个主要问题是胰腺中产生胰岛素的β细胞的丧失。重新填充β细胞需要对调节其生长和维持其功能的因素进行彻底分析。一种重要的细胞类型