Probing the role of dopamine in co-morbid pathological gambling and Parkinson's disease: Behavioural pharmacology, electrophysiology, neuroimaging, and genetics.

探讨多巴胺在共病病理性赌博和帕金森病中的作用：行为药理学、电生理学、神经影像学和遗传学。

• 批准号: 176477
• 负责人: Zack Martin H
• 金额: --
• 依托单位: Centre for Addiction and Mental Health (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-10-01 至 2009-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=176477&lang=en
• 关键词: Amphetamine; Behavioural Pharmacology; Dopamine Agonist; Electrophysiology; Parkinson'S Disease; Pathological Gambling; Positron Emission Tomography; Pramipexole; Reward Seeking; Risk-Taking

Dopamine (DA) agonists are very effective medications for Parkinson's disease (PD) but can also trigger pathological gambling (PG) in 7-15% of PD patients (3-5 times the population rate). Risk factors for PG in PD are the same as in the general population

多巴胺(DA)激动剂是治疗帕金森氏病(PD)的非常有效的药物，但也可以在7-15%的PD患者中引发病理性赌博(PG)(是总人口的3-5倍)。PD患者发生PG的危险因素与普通人群相同