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Comparative effects of a D2 and mixed D1-D2 dopamine antagonist on gambling and amphetamine reinforcement in pathological gamblers and healthy controls

Comparative effects of a D2 and mixed D1-D2 dopamine antagonist on gambling and amphetamine reinforcement in pathological gamblers and healthy controls
D2 和混合 D1-D2 多巴胺拮抗剂对病态赌徒和健康对照者赌博和安非他明强化的比较影响
批准号：
179695
负责人：
Zack Martin H
金额：
$30.09万
依托单位：
Centre for Addiction and Mental Health (Toronto)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2009
资助国家：
加拿大
项目状态：
已结题
起止时间：
2009-03-01 至 2012-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=179695&lang=en
关键词：
Amphetamine D1 And D2 Receptors Dopamine Antagonists Pathological Gambling Priming Reinforcement

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英文摘要
Pathological gambling is a serious disorder that afflicts 2-3% of Canadians. There are currently no medications approved to treat it. Better understanding of the neurochemistry of pathological gambling could inform medication development. Evidence suggest
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Probing the role of dopamine in co-morbid pathological gambling and Parkinson's disease: Behavioural pharmacology, electrophysiology, neuroimaging, and genetics.
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