Building Molecular Complexity Through Enzyme-Enabled Synthesis

通过酶合成构建分子复杂性

• 批准号: DE240100502
• 负责人: Dr Lauren Murray
• 金额: $ 29.42万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE240100502
• 关键词: Building; Molecular; Complexity; Through; Enzyme

Many valuable natural molecules are too complex to be commercially synthesised by current technologies. Despite advances in synthetic chemistry there is great need to adopt the elegant biocatalytic strategies for complex molecule synthesis found in nature, employing sophisticated enzyme catalysts. This interdisciplinary research program aims to address the shortcomings of traditional synthetic methods through the development of enzyme catalysts to rapidly generate complex molecular structures. These novel molecules can be readily converted into pharmaceuticals and agrochemicals leading to advancements in the bio-enabled production and application of organic molecules in these vital fields.

许多有价值的天然分子过于复杂，无法用现有技术进行商业合成。尽管合成化学取得了进步，但仍然非常需要采用自然界中发现的复杂分子合成的优雅生物催化策略，使用复杂的酶催化剂。这个跨学科的研究项目旨在通过开发酶催化剂来解决传统合成方法的缺点，以快速生成复杂的分子结构。这些新型分子可以很容易地转化为药物和农用化学品，从而促进了有机分子在这些重要领域的生物生产和应用。