Building Molecular Complexity Through Enzyme-Enabled Synthesis

通过酶合成构建分子复杂性

• 批准号: DE240100502
• 负责人: Dr Lauren Murray
• 金额: $ 29.42万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE240100502
• 关键词: Building; Molecular; Complexity; Through; Enzyme

Many valuable natural molecules are too complex to be commercially synthesised by current technologies. Despite advances in synthetic chemistry there is great need to adopt the elegant biocatalytic strategies for complex molecule synthesis found in nature, employing sophisticated enzyme catalysts. This interdisciplinary research program aims to address the shortcomings of traditional synthetic methods through the development of enzyme catalysts to rapidly generate complex molecular structures. These novel molecules can be readily converted into pharmaceuticals and agrochemicals leading to advancements in the bio-enabled production and application of organic molecules in these vital fields.

许多有价值的天然分子太复杂，无法通过现有技术进行商业合成。尽管在合成化学方面取得了进展，但仍然非常需要采用优雅的生物催化策略来合成自然界中发现的复杂分子，采用复杂的酶催化剂。该跨学科研究计划旨在通过开发酶催化剂来解决传统合成方法的缺点，以快速生成复杂的分子结构。这些新型分子可以很容易地转化为药物和农用化学品，从而推动了这些重要领域中有机分子的生物生产和应用。