Large volume preparative ultracentrifuge for the enhancement of membrane biophysics research at Guelph

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Biological membranes are multifunctional proteolipid complexes, responsible for the multitude of vital cellular functions, including sensing, bioenergetics, transport, and enzymatic activities. Membrane biophysics group at Guelph studes structure and dynamics of lipid membranes, structure/function relationship in membrane transporters and photosensors, as well as interaction of proteins and peptides with membranes. Preparation of the samples for biophysical studies by advanced spectroscopic and microscopic techniques includes ultracentrifugation of relatively large volumes, this is why having a dedicated large volume ultracentrifuge is essential. The requested ultracentrifuge will advance research of many graduate and undergraduate students, as well as postdoctoral fellows, who work on fundamental projects related, among other topics, to effects of cholesterol on biological membranes, medically important human membrane proteins, bacterial pathogenesis, and mechanism of action of antimicrobial compounds.