Synthetic Toll-like Receptor 4 Agonists as Potential Adjuvants for Use in Animal Vaccines

合成 Toll 样受体 4 激动剂作为动物疫苗中的潜在佐剂

• 批准号: 428767-2011
• 负责人: Jiang, ZiHua
• 金额: $ 1.82万
• 依托单位: Lakehead University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=496369
• 关键词: Synthetic; Toll; like; Receptor; Agonists

Adjuvants play an essential role in the development of new vaccines to combat life-threatening diseases in companion animals as well as livestock. Vaccine protection is a particular concern in agriculture where farming depends on maintaining health in herd animals. Improvement of existing animal vaccines with the development of novel adjuvants could also potentially increase their safety and efficacy. Currently there are only a few adjuvants available for vaccines in animal use, and therefore there is an urgent need to develop and characterize new adjuvants.

佐剂在开发新疫苗以对抗伴侣动物和牲畜中危及生命的疾病方面发挥着至关重要的作用。疫苗保护在农业中是一个特别令人关注的问题，因为农业依赖于保持畜群动物的健康。通过开发新的佐剂来改进现有的动物疫苗也可能提高其安全性和有效性。目前，只有少数佐剂可用于动物使用的疫苗，因此迫切需要开发和表征新的佐剂。